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Some epidemiological studies have shown that domperidone may be associated with a small increased risk of serious ventricular arrhythmia or sudden cardiac death. These risks may be higher in patients older than 60 years and in patients who receive daily oral doses of more than 30 mg. Non-prescription domperidone products are not recommended for use in patients with underlying cardiac disease, without medical supervision.
Further reading available here: http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON152725
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